Review ArticlesMolecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive PerspectiveToper, M. Hasan MD; Sarioglu, Sulen MDAuthor Information Department of Molecular Pathology, Graduate School of Health Sciences, Dokuz Eylul University, Izmir, Turkey The authors have no funding or conflicts of interest to disclose. Reprints: M. Hasan Toper, MD, Department of Molecular Pathology, Graduate School of Health Sciences, Dokuz Eylul University, Mithatpasa St. No:1606 Inciralti Health Campus, 35340 Inciralti/Izmir, Turkey (e-mail: [email protected]). Advances In Anatomic Pathology: March 2021 - Volume 28 - Issue 2 - p 81-93 doi: 10.1097/PAP.0000000000000291 Buy Metrics Abstract Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chromosomal rearrangements including CRTC1-MAML2 and CRTC3-MAML2 in mucoepidermoid carcinoma, MYB-NFIB and MYBL1-NFIB fusions in adenoid cystic carcinoma, PLAG1 and HMGA2 alterations in pleomorphic adenoma and carcinoma ex pleomorphic adenoma, ETV6-NTRK3 and ETV6-RET in secretory carcinoma, EWSR1-ATF1 and EWSR1-CREM in clear cell carcinoma, provide new insights into the molecular pathogenesis of various salivary gland neoplasms and help to better classify them. These genetic aberrations primarily serve as diagnostic tools in salivary gland tumor diagnosis; however, some also have promise as prognostic or predictive biomarkers. This review summarizes the latest developments in molecular pathology of salivary gland tumors with a focus on distinctive molecular characteristics. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.