Review ArticlesThe Evolving Spectrum of Precursor Lesions of Cervical AdenocarcinomasStolnicu, Simona MD*; Talia, Karen L. FRCPA†; McCluggage, W. Glenn FRCPath‡Author Information *Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, Romania †VCS Pathology, VCS Foundation, Carlton, Vic., Australia ‡Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK S.S. and K.L.T. contributed equally to the paper. The authors have no funding or conflicts of interest to disclose. All figures can be viewed online in color at www.anatomicpathology.com. Reprints: W. Glenn McCluggage, FRCPath, Department of Pathology, Belfast Health and Social Care Trust, Grosvenor Road, Belfast, BT12 6BA, UK (e-mail: [email protected]). Advances In Anatomic Pathology: September 2020 - Volume 27 - Issue 5 - p 278-293 doi: 10.1097/PAP.0000000000000266 Buy Metrics Abstract Modern classification schemes divide cervical adenocarcinomas into human papillomavirus (HPV)-associated and HPV-independent types. The precursor lesions of the former are well known and comprise HPV-associated (usual/endocervical) adenocarcinoma in situ (AIS) and the much less common stratified mucin–producing intraepithelial lesion (SMILE). The precursor lesions of HPV-independent cervical adenocarcinomas are much less well known, although postulated precursors of gastric-type adenocarcinoma include atypical lobular endocervical glandular hyperplasia and gastric-type AIS. In this review, we cover HPV-associated and HPV-independent precursor lesions of cervical adenocarcinomas concentrating on diagnostic criteria (morphology and immunophenotype) and differential diagnosis. We propose a uniform terminology and diagnostic criteria for precursor lesions showing intestinal differentiation with goblet cells because this may be a feature of both HPV-associated and HPV-independent AIS. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.