Review ArticlesUpdates on the Genomics of Bladder Cancer and Novel Molecular TaxonomyAl-Ahmadie, Hikmat MD*; Netto, George J. MD†Author Information *Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY †Department of Pathology, University of Alabama at Birmingham, Birmingham, AL Supported in part by Sloan Kettering Institute for Cancer Research Cancer Center Support Grant P30CA008748 and by SPORE in Bladder Cancer P50CA221745. The authors have no funding or conflicts of interest to disclose. All figures can be viewed online in color at www.anatomicpathology.com. Reprints: Hikmat Al-Ahmadie, MD, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (e-mail: [email protected]). Advances In Anatomic Pathology: January 2020 - Volume 27 - Issue 1 - p 36-43 doi: 10.1097/PAP.0000000000000252 Buy SDC Metrics Abstract Urothelial carcinoma (UC) is the most common malignant neoplasm of the bladder that encompasses a wide spectrum of histopathologic features and various molecular alterations and subtypes, responsible for its significant morphologic and genomic heterogeneity. Morphologically, in addition to classic UC (not otherwise specified), many well documented variant histologies are a common finding in invasive UC, and include squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of UC and variant histologies. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.