Utility of Cyclin D1 in the Diagnostic Workup of Hematopoietic Neoplasms What Can Cyclin D1 Do for Us?Wang, Wei MD, PhD; Medeiros, L. Jeffrey MDAdvances in Anatomic Pathology: September 2019 - Volume 26 - Issue 5 - p 281–291 doi: 10.1097/PAP.0000000000000241 Review Articles Buy Abstract Author InformationAuthors Article MetricsMetrics Cyclin D1, encoded by CCND1, promotes cell cycle progression from G1 to S phase. Its expression is induced by MAPK/ERK pathway as well as translocations/rearrangements involving CCND1 gene. The evaluation of cyclin D1 expression by immunohistochemistry plays an important role in the diagnostic workup of various hematopoietic diseases. In this review, we aimed to discuss the value of cyclin D1 immunostain in the diagnosis and different diagnosis of hematopoietic neoplasms. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX The authors have no funding or conflicts of interest to disclose. All figures can be viewed online in color at www.anatomicpathology.com. Reprints: Wei Wang, MD, PhD, Department of Hematopathology, Unit 72, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 (e-mail: email@example.com). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.