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Utility of Cyclin D1 in the Diagnostic Workup of Hematopoietic Neoplasms

What Can Cyclin D1 Do for Us?

Wang, Wei MD, PhD; Medeiros, L. Jeffrey MD

doi: 10.1097/PAP.0000000000000241
Review Articles

Cyclin D1, encoded by CCND1, promotes cell cycle progression from G1 to S phase. Its expression is induced by MAPK/ERK pathway as well as translocations/rearrangements involving CCND1 gene. The evaluation of cyclin D1 expression by immunohistochemistry plays an important role in the diagnostic workup of various hematopoietic diseases. In this review, we aimed to discuss the value of cyclin D1 immunostain in the diagnosis and different diagnosis of hematopoietic neoplasms.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

The authors have no funding or conflicts of interest to disclose.

All figures can be viewed online in color at

Reprints: Wei Wang, MD, PhD, Department of Hematopathology, Unit 72, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 (e-mail:

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