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Review of Drug-induced Injury in Mucosal Biopsies From the Tubular Gastrointestinal Tract

Allard, Felicia D., MD*; Stelow, Edward B., MD

Advances in Anatomic Pathology: May 2019 - Volume 26 - Issue 3 - p 151–170
doi: 10.1097/PAP.0000000000000230
Review Articles

The use of prescription and over-the-counter medications is on the rise in the US population, especially among those aged 65 and over, with over 46% of the population taking at least 1 prescription medication. Given the frequency of medication use, and that the majority of these medications are taken orally, it has become increasingly relevant for pathologist examining endoscopically obtained gastrointestinal tract mucosal biopsies to consider and recognize patterns of mucosal injury associated with various drugs. Reports on injuries associated with certain classes of drugs can be scattered among different sources, making a comprehensive view of various injury patterns and the drugs known to cause them difficult to obtain. Herein, we provide a comprehensive overview of the drugs known to cause mucosal injuries in the tubular gastrointestinal tract organized by the organ involved and the prominent pattern of injury.

*Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR

Department of Pathology, University of Virginia, Charlottesville, VA

F.D.A.: conceptualization, data curation and writing—original draft preparation. E.B.S.: conceptualization, writing—review and editing, and supervision.

The authors have no funding or conflicts of interest to disclose.

All figures can be viewed online in color at

Reprints: Felicia D. Allard, MD, Department of Pathology, University of Arkansas for Medical Science, 4301 W. Markham St., #517, Little Rock, AR 72205-7199 (e-mail:

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