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Evolution in Prostate Cancer Staging: Pathology Updates From AJCC 8th Edition and Opportunities That Remain

Fine, Samson W., MD

doi: 10.1097/PAP.0000000000000200
Review Articles

The Tumor-Nodes-Metastasis system at the core of prognostic staging has been recently updated in the American Joint Committee on Cancer (AJCC) 8th edition, published in 2016. For prostate cancer, significant changes in staging of organ-confined disease, inclusion of a new grade grouping, and provision of levels of evidence for these modifications are part of what differentiates the 8th edition AJCC from prior iterations. Herein, the rationale underlying these changes is detailed. In addition, data elements not well represented in the present system are highlighted as opportunities for fresh study that may impact future AJCC classifications.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY

The authors have no funding or conflicts of interest to disclose.

Reprints: Samson W. Fine, MD, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C502, New York, NY 10065 (e-mail: figures can be viewed online in color at

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