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Recent Advances in the Classification of Low-grade Papillary-like Thyroid Neoplasms and Aggressive Papillary Thyroid Carcinomas

Evolution of Diagnostic Criteria

Guo, Zhenying, MD*,†; Ge, Minghua, MD*,†; Chu, Ying-Hsia, MD; Asioli, Sofia, MD§; Lloyd, Ricardo V., MD, PhD

Advances in Anatomic Pathology: July 2018 - Volume 25 - Issue 4 - p 263–272
doi: 10.1097/PAP.0000000000000198
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Papillary thyroid carcinomas account for ∼80% of well-differentiated thyroid tumors. During the past decade, several new variants of papillary-like thyroid neoplasms and papillary thyroid carcinomas have been recognized. Some of these neoplasms that were previously classified as malignant have been reclassified as low-grade neoplasms, as the diagnostic criteria have evolved. Similarly, some of the papillary thyroid carcinomas that were previously classified as conventional or classic papillary thyroid carcinomas have now been recognized as more aggressive variants of papillary thyroid carcinomas. Recognizing these differences becomes more important for the proper medical, surgical, and radiotherapeutic management of patients with these neoplasms

Departments of *Pathology

Head & Neck Surgery, Zhejiang Cancer Hospital, Zhejiang, China

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI

§Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology “M. Malpighi” at Bellaria Hospital, University of Bologna, Bologna, Italy

Supported by Zhejiang Provincial Natural Science Foundation of China (LY16H160036—Z.G.) and National Natural Science Foundation of China (No. 81602348—Z.G.) by National Natural Science Foundation of China (No. 81672642—M.G.) and by the University of Wisconsin Carbone Cancer Center Cancer Center Support Grant P30 CA014520 (R.V.L.).

The authors have no funding or conflicts of interest to disclose.

Reprints: Ricardo V. Lloyd, MD, PhD, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53706 (e-mail: rvlloyd@wisc.edu).

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