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Clinical Applications of Whole-slide Imaging in Anatomic Pathology

Volynskaya, Zoya PhD; Evans, Andrew J. MD, PhD; Asa, Sylvia L. MD, PhD

Advances In Anatomic Pathology: July 2017 - Volume 24 - Issue 4 - p 215–221
doi: 10.1097/PAP.0000000000000153
Review Articles

The development of whole-slide imaging has paved the way for digitizing of glass slides that are the basis for surgical pathology. This transformative technology has changed the landscape in research applications and education but despite its tremendous potential, its adoption for clinical use has been slow. We review the various niche applications that initiated awareness of this technology, provide examples of clinical use cases, and discuss the requirements and challenges for full adoption in clinical diagnosis. The opportunities for applications of image analysis tools in a workflow will be changed by integration of whole-slide imaging into routine diagnosis.

Laboratory Medicine Program, Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada

S.L.A. is a member of the Medical Advisory Board of Leica Biosystems Pathology Imaging. The remaining authors have no funding or conflicts of interest to disclose.

Reprints: Sylvia L. Asa, MD, PhD, Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, Canada M5G 2C4 (e-mail:

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