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The Origin of Epithelial Neoplasms of the Ovary: An Alternative View

Silva, Elvio G. MD*,†

Advances In Anatomic Pathology: January 2016 - Volume 23 - Issue 1 - p 50–57
doi: 10.1097/PAP.0000000000000098
Review Articles

Several theories have been proposed to explain the origin of epithelial neoplasms of the ovary. However, most of them did not receive serious consideration until recently when it has been proposed that most ovarian neoplasms arise from the fallopian tube. In this review, we mention the different theories, we discuss in detail the fallopian tube theory, and the reasons why this theory is probably inaccurate. We are also proposing a new theory, the fere ex nihilo, based on the observation of numerous cases, old and new concept, and experimental works with animals. We believe that, most probably, ovarian epithelial neoplasms are related to hormones and the identification of these hormones will allow us not only to diagnose and treat these lethal neoplasms, but also to prevent them.

*Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA

Baylor University Hospital, The University of Texas MD Anderson Cancer Center, Houston, TX

The author has no NIH funding or conflicts of interest to disclose.

Reprints: Elvio G. Silva, MD, Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, PACT 500, Los Angeles, CA 90048 (e-mail:

All figures can be viewed online in color at

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.