Review ArticlesSystemic Lupus Erythematosus–associated Neutrophilic Dermatosis A Review and UpdateLarson, Allison R. MD; Granter, Scott R. MDAuthor Information Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston MA The authors have no funding or conflicts of interest to disclose. Reprints: Scott R. Granter, MD, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St. J-820, Jimmy Fund Building, Boston, MA 02115 (e-mail: [email protected]). Advances In Anatomic Pathology: July 2014 - Volume 21 - Issue 4 - p 248-253 doi: 10.1097/PAP.0000000000000026 Buy Metrics Abstract Neutrophilic dermatoses are a rare manifestation of systemic lupus erythematosus (SLE). In recent years, a growing body of literature describes a pathologic spectrum of neutrophilic infiltrates that may be seen in lupus patients. It is particularly important to recognize that neutrophilic dermatoses can be the initial manifestation of SLE in a third of patients. We were able to identify 47 patients with SLE associated with neutrophilic tissue reactions. In this review, we describe the histologic and clinical features of these cases in the hope that increased awareness of this unusual manifestation of SLE will generate prompt diagnosis and improved patient care. © 2014 by Lippincott Williams & Wilkins.