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“Lentiginous Melanoma”: Full-fledged Melanoma or Melanoma Precursor?

Mooi, Wolter J. MD

Advances in Anatomic Pathology: May 2014 - Volume 21 - Issue 3 - p 181–187
doi: 10.1097/PAP.0000000000000013
Review Articles

On the basis of a critical review of published literature, it is concluded that there is as yet insufficient evidence to conclude that the melanocytic lesion, which is currently known as “lentiginous melanoma,” is a full-fledged melanoma, with the capacity to metastasize to distant sites and to cause the demise of the patient. It is proposed that this lesion is better designated as “lentiginous SAMPUS,” that is, a superficial atypical melanocytic proliferation of uncertain significance, with a lentiginous, or predominantly lentiginous, arrangement of the junctional component. As there is uncertainty regarding its actual metastatic potential or the likelihood of progression to melanoma NOS, the lesion should be removed completely, with free surgical margins.

Department of Pathology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands

The author has no NIH funding or conflicts of interest to disclose.

Reprints: Wolter J. Mooi, MD, Department of Pathology, Room 3E43, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands (e-mail:

All figures can be viewed online in color at

© 2014 by Lippincott Williams & Wilkins.