Review ArticlesOncocytic Lesions of the Neuroendocrine SystemCanberk, Sule MD; LiVolsi, Virginia A. MD; Baloch, Zubair MD, PhDAuthor Information Department of Pathology and Laboratory Medicine, Perelman School of Medicine, UPENN Medical Center, Philadelphia, PA The authors have no funding or conflicts of interest to disclose. Reprints: Zubair Baloch, MD, PhD, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, UPENN Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104 (e-mail: [email protected]).All figures can be viewed online in color at http://www.anatomicpathology.com. Advances In Anatomic Pathology: March 2014 - Volume 21 - Issue 2 - p 69-82 doi: 10.1097/PAP.0000000000000011 Buy Metrics Abstract This paper reviews the pathologic features of lesions which are oncocytic and involve classic endocrine organs. The history of the oncocytic cell, its morphologic and ultrastructural features, and important immunohistochemical findings are reviewed. Oncocytic proliferations including non-neoplastic and neoplastic of the thyroid, parathyroid, adrenal (both cortex and medulla), and pituitary are described. Their clinical relevance, functional capacity and capability, and where appropriate, prognostic implications are discussed. Important and relevant molecular biological information is included where appropriate. © 2014 by Lippincott Williams & Wilkins.