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Cutaneous Neoplasms Showing EWSR1 Rearrangement

Boland, Jennifer M. MD; Folpe, Andrew L. MD

Advances In Anatomic Pathology: March 2013 - Volume 20 - Issue 2 - p 75–85
doi: 10.1097/PAP.0b013e31828625bf
Review Articles

Rearrangements of the EWSR1 gene are found in an increasing number of human neoplasms, including several tumors that can involve the skin: Ewing sarcoma/primitive neuroectodermal tumor, angiomatoid (malignant) fibrous histiocytoma, myoepithelioma of soft tissue, and clear cell sarcoma. Although these tumors share this common genetic link, they have very different clinical features, morphology, immunophenotype, and sometimes fusion gene partners; these will be the subjects of this review.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

The authors have no funding or conflicts of interest to disclose.

All figures can be viewed online in color at

Reprints: Andrew L. Folpe, MD, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905 (e-mail:

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