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Human Correlates of Provocative Questions in Pancreatic Pathology

McDonald, Oliver G. MD, PhD; Maitra, Anirban MBBS; Hruban, Ralph H. MD

doi: 10.1097/PAP.0b013e318273f998
Review Articles

Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no contact with human pathology have challenged the way that pancreatic pathology is practiced, suggesting that “genetic signals” may be more accurate than today’s multimodal approach to diagnoses. In this review, we consider 8 provocative issues in pancreas pathology, with an emphasis on “the evidence derived from man.”

Departments of *Pathology


Institute for Genetic Medicine, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD

Supported by NIH Grant P50CA062924 and the Ruth Kirschstein National Research Service Award (T32 CA067751).

The authors have no conflicts of interest to disclose.

Reprints: Ralph H. Hruban, MD, Department of Pathology, The Johns Hopkins Hospital, Weinberg Building Room 2242, 401 North Broadway, Baltimore, MD 21231 (e-mail: All figures can be viewed online in color at

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.