Review ArticlesThe Clinical Significance of Recognizing Distinct Morphologic Features of Systemic Diseases on Breast BiopsiesMasood, Shahla MD; Davis, Cindy Lee MD, MEd; Kubik, Melanie Jennifer MDAuthor Information Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Jacksonville, FL The authors have no funding or conflicts of interest to disclose. Reprints: Shahla Masood, MD, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, 655 West 8th St., Box C-505, Jacksonville, FL 32209 (e-mail: [email protected]). Advances In Anatomic Pathology: July 2012 - Volume 19 - Issue 4 - p 217-219 doi: 10.1097/PAP.0b013e31825c6b58 Buy Metrics Abstract Prominent lymphocytic periductal inflammation has been previously described in association with diabetes mellitus type I and II, other autoimmune diseases such as lupus, thyroid disease, and connective tissue abnormalities, and even lymphomas. When incidentally detected in a breast biopsy and without evidence of systemic disease in the patient’s history, it may be prudent to alert the treating clinician to the possibility of an underlying systemic disease process, in order to ensure recognition and appropriate clinical follow-up for these patients. The purpose of this review is to familiarize the reader with this commonly encountered incidental feature on breast biopsies and to emphasize the importance and clinical implications of recognizing possible underlying systemic disease and communicating these findings to the treating physicians. Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.