Review ArticlesPrimary Mediastinal “Thymic” SeminomasWeissferdt, Annikka MD, FRCPath*; Suster, Saul MD†; Moran, Cesar A. MD*Author Information *Department of Pathology at the University of Texas, MD Anderson Cancer Center, Houston, TX †Medical College of Wisconsin, Milwaukee, WI The authors have no funding or conflicts of interest to disclose. Reprints: Annikka Weissferdt MD, FRCPath, Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030 (e-mail: [email protected]). Advances In Anatomic Pathology: March 2012 - Volume 19 - Issue 2 - p 75-80 doi: 10.1097/PAP.0b013e318248b725 Buy Metrics Abstract Over the last half century, our knowledge on germ cell tumors (GCT) has increased dramatically. Tumors that at one time were supposed to originate exclusively from certain anatomic areas are now thought to occur in ubiquitous distribution. Nevertheless, because of their similar histopathologic features, the conventional classic evaluation of these patients will require careful clinical history as well as complete physical and radiologic evaluation. The emphasis in this manuscript will be to highlight the occurrence and overall characteristics of one of the most common GCTs in the mediastinal region—seminoma. A more detailed discussion of mediastinal GCTs is well beyond the scope of this review. © 2012 Lippincott Williams & Wilkins, Inc.