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Strategies for Distinguishing Low-grade Endometrioid and Serous Carcinomas of Endometrium

Garg, Karuna MD; Soslow, Robert A. MD

Advances in Anatomic Pathology: January 2012 - Volume 19 - Issue 1 - p 1–10
doi: 10.1097/PAP.0b013e318234ab36
Review Articles

Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are occasional problematic cases. This review focuses on strategies that help differentiate between low-grade endometrioid carcinoma and serous carcinoma of the endometrium. We will discuss clinical, morphologic, and immunohistochemical differences between the 2 entities and provide practical tips for practicing pathologists when confronted with this differential diagnosis.

Department of Pathology, Memorial Sloan Kettering Cancer Center, York Avenue, New York, NY

The authors have no funding or conflicts of interest to disclose.

Reprints: Karuna Garg, MD, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.