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Pediatric Fibroblastic and Myofibroblastic Lesions

Thway, Khin MBBS, BSc, FRCPath*; Fisher, Cyril MD, DSc, FRCPath*; Sebire, Neil J. MD, FRCPath

Advances in Anatomic Pathology: January 2012 - Volume 19 - Issue 1 - p 54–65
doi: 10.1097/PAP.0b013e31823d76ed
Review Articles

Fibrous lesions of infancy and childhood are a heterogeneous group of entities composed predominantly of fibroblasts and myofibroblasts, ranging from reactive lesions to neoplasms with a range of malignant potential. Although rare, their correct recognition by histopathology is important clinically as they exhibit a wide range of behaviors and may be associated with distinct underlying syndromes. Contributions from molecular diagnostics have enabled more accurate diagnosis, and have changed our concepts of some tumor types. In this review, we discuss the clinicopathologic spectrum of fibroblastic and myofibroblastic lesions of childhood and adolescence.

*Department of Histopathology, The Royal Marsden NHS Foundation Trust

Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital for Children, Great Ormond Street, London, UK

All figures can be viewed online in color at

The authors acknowledge NHS funding to the NIHR Biomedical Research Centre. The authors have no conflicts of interest to disclose.

Reprints: Khin Thway, MBBS, BSc, FRCPath, Department of Histopathology, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK (e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.