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Pineal Tumors

Dahiya, Sonika MD*; Perry, Arie MD

doi: 10.1097/PAP.0b013e3181f895a4
Review Articles

Pineal tumors are a rare and heterogeneous group of primary central nervous system neoplasms, including pineal parenchymal tumors (pineocytomas, pineal parenchymal tumors of intermediate differentiation, and pineoblastomas), germ cell tumors, and neuroepithelial tumors, such as astrocytomas, ependymomas, and papillary tumor of the pineal region. Their classification has evolved over time, with several updates incorporated into the most recent World Health Organization classification, published in 2007. This review highlights the most recent classification and grading scheme for pineal parenchymal tumors and discusses the newly recognized papillary tumor of the pineal region, including clinicopathologic features, differential diagnosis, and management options.

*Department of Pathology, Washington University School of Medicine, St Louis, MO

Department of Pathology, University of California and San Francisco, San Francisco, CA

All figures can be viewed online in color at

Reprints: Arie Perry, MD, Department of Pathology, University of California and San Francisco, 505 Parnassus Avenue, Room M-551, Box 0102, San Francisco, CA 94143-0102 (e-mail:

© 2010 Lippincott Williams & Wilkins, Inc.