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Adenocarcinoma of the Upper Aerodigestive Tract

Stelow, Edward B. MD*; Mills, Stacey E. MD*; Jo, Vickie Y. MD*; Carlson, Diane L. MD

Advances in Anatomic Pathology: July 2010 - Volume 17 - Issue 4 - p 262-269
doi: 10.1097/PAP.0b013e3181e3bf80
Review Articles

Although squamous cell carcinoma is the most frequent malignant diagnosis made with upper aerodigestive tract specimens, a myriad of neoplasms can occur throughout the area. Very uncommonly, one encounters adenocarcinomas that cannot be better classified as salivary gland-type neoplasia. This manuscript reviews these tumors, including sinonasal intestinal-type adenocarcinomas, sinonasal low-grade and high-grade nonintestinal adenocarcinomas and nasopharyngeal papillary adenocarcinomas. Clinical, histologic, and immunohistochemical features and differential diagnoses are discussed.

*Department of Pathology, University of Virginia, Charlottesville, VA

Cleveland Clinic Florida, Department of Lab Medicine and Pathology, Weston, FL

Reprints: Diane L. Carlson, MD, Cleveland Clinic Florida, Department of Lab Medicine and Pathology, 3100 Weston Rd, Weston, FL 33331 (e-mail:

All figures can be viewed online in color at

© 2010 Lippincott Williams & Wilkins, Inc.