Review ArticlesPancreas Transplant Recent Advances and Spectrum of Features in Pancreas Allograft PathologyPatil, Deepa T. MD; Yerian, Lisa M. MD Author Information Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH Reprints: Lisa M. Yerian, MD, Department of Anatomic Pathology/L-25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195 (e-mail: [email protected]). All figures can be viewed online in colour at http://www.anatomicpathology.com. Advances in Anatomic Pathology: May 2010 - Volume 17 - Issue 3 - p 202-208 doi: 10.1097/PAP.0b013e3181d97635 Buy Metrics Abstract As result of improved surgical techniques and newer immunosuppressive regimens contributing significantly to better graft survival, exocrine pancreas transplantation remains the standard treatment of choice for patients with diabetes mellitus complicated by end-stage renal disease. Histologic assessment continues to play an important role in the diagnosis of graft complications after pancreas transplantation, especially for evaluating allograft rejection where histopathology is still considered the gold standard. This review elaborates on the current types of pancreas transplants and focuses on the patterns of allograft injury that are encountered in posttransplantation pancreas biopsies along with the pertinent differential diagnoses. In addition to optimal histologic assessment, as in any other organ transplant setting, clinical information including indication and duration of transplant as well as other serologic work-up must be taken into consideration during clinical decision making for optimal graft outcome. © 2010 Lippincott Williams & Wilkins, Inc.