Review ArticlesGoblet or Signet Ring Cells That is the QuestionWang, Hanlin L. MD, PhD; Dhall, Deepti MDAuthor Information Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA Reprints: Hanlin L. Wang, MD, PhD, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 (e-mail: [email protected]). All figures can be viewed online in color at http://www.anatomicpathology.com. Advances in Anatomic Pathology: July 2009 - Volume 16 - Issue 4 - p 247-254 doi: 10.1097/PAP.0b013e3181a9d49a Buy Metrics Abstract Goblet cell carcinoid tumor is a rare mixed endocrine-exocrine neoplasm of the appendix. It carries an intermediate biologic behavior between a classic carcinoid tumor and a conventional adenocarcinoma. There has been a general lack of clinicopathologic parameters that can be reliably used to predict the clinical course and patient outcome. A recent retrospective study of a large number of appendiceal goblet cell carcinoids has shown that these tumors can be stratified into 3 subgroups based on careful histologic analysis: typical goblet cell carcinoid (group A); adenocarcinoma ex goblet cell carcinoid, signet ring cell type (group B); and adenocarcinoma ex goblet cell carcinoid, poorly differentiated carcinoma type (group C). Clinical follow-up data show that the histologic classification correlates with patient survival. Thus, meticulous histologic evaluation is of critical importance in determining the prognosis and guiding the management of patients with goblet cell carcinoids. This brief review summarizes these recent findings and raises a few issues that may need to be further addressed to better apply this classification to our practice. © 2009 Lippincott Williams & Wilkins, Inc.