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Seeking Beyond Rejection: An Update on the Differential Diagnosis and a Practical Approach to Liver Allograft Biopsy Interpretation

Gao, Zu-hua MD, PhD, FRCPC

Advances in Anatomic Pathology: March 2009 - Volume 16 - Issue 2 - p 97-117
doi: 10.1097/PAP.0b013e31819946aa
Review Articles
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Pathologic evaluation of liver allograft biopsies plays an integral role in the management of patients after liver transplantation. This review summarizes the clinical context and classical histology of different types of allograft rejection and also the common entities that enter the differential diagnosis of allograft rejection, and provides practical approaches to liver allograft biopsy interpretation. In addition, some of the new developments in the field of liver transplant pathology are updated. The purpose of this review is to provide guidance for pathologists interpreting liver allograft biopsies, particularly those interested in developing expertise in the field of liver transplant pathology.

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada

Reprints: Zu-hua Gao, MD, PhD, FRCPC, Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Foothills Medical Center, Room C1150E, 1403-29 Street NW, Calgary, Alberta, Canada T2N 2T9 (e-mail: zuhuagao@hotmail.com).

© 2009 Lippincott Williams & Wilkins, Inc.