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Calretinin: Diagnostic Utility in the Female Genital Tract

Portugal, Raquel MD; Oliva, Esther MD

Advances in Anatomic Pathology: March 2009 - Volume 16 - Issue 2 - p 118-124
doi: 10.1097/PAP.0b013e31819923ce
Review Articles

The utility of calretinin was first described in the diagnosis of mesothelioma. In the female genital tract, calretinin was initially reported in Wolffian remnants and related lesions and later used in the diagnosis of sex cord stromal tumors of the ovary, endometrial stromal tumors with sex cord-like differentiation, and uterine tumors resembling sex cord tumors of the ovary. This review discusses calretinin expression in normal tissues of the female genital tract and highlights its potential utility in the diagnosis of these subsets of neoplasms with emphasis to tumors that may constitute a problem in their differential diagnosis. In particular, the limited utility of calretinin in the diagnosis of sex cord stromal tumors of the ovary, in the differential diagnosis between mesothelioma and serous tumors involving the ovary and/or peritoneum, and in the differential diagnosis between Wolffian lesions and endometrial carcinoma are addressed.

Massachusetts General Hospital, Boston, MA

Reprints: Esther Oliva, MD, Massachusetts General Hospital, 55 Fruit Street, Boston, MA (e-mail:

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© 2009 Lippincott Williams & Wilkins, Inc.