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Solid Pseudopapillary Tumor of the Pancreas: A Review of Salient Clinical and Pathologic Features

Adams, Amy L. MD; Siegal, Gene P. MD, PhD; Jhala, Nirag C. MD

Advances in Anatomic Pathology: January 2008 - Volume 15 - Issue 1 - p 39-45
doi: 10.1097/PAP.0b013e31815e5237
Review Articles

Solid pseudopapillary tumor (SPT) of the pancreas is a rare tumor of uncertain histogenesis characterized, as the name suggests, by a cystic and solid pattern of growth with formation of pseudopapillae. Accounting for only a small percentage of pancreatic neoplasms, SPT occurs primarily in young women, although cases in older patients and men have been reported. The tumor is thought to have low-grade malignant potential, as the majority of the cases are cured by simple but complete surgical resection. Knowledge of the unique morphologic and demographic characteristics of this neoplasm is essential for accurate diagnosis. Herein, we review the clinical and pathologic features, which can help separate SPTs from other primary pancreatic tumors.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249

Reprints: Amy L. Adams, MD, Department of Pathology, University of Alabama at Birmingham, 1802 Sixth Avenue South, NP3548, Birmingham, AL 35249 (e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.