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Use of Immunohistochemistry in Diagnosis of Breast Epithelial Lesions

Bhargava, Rohit MD; Dabbs, David J. MD

Advances in Anatomic Pathology: March 2007 - Volume 14 - Issue 2 - p 93-107
doi: 10.1097/PAP.0b013e31803244d5
Review Articles

In recent years, the use of immunohistochemistry (IHC) in breast pathology has increased tremendously. It is not because the new genre of breast pathologists are less well trained than their “experienced” counterparts; it is mainly because of the demands of more accurate and precise diagnoses, identification of new entities and availability of novel antibodies. The main purpose of this review is to discuss the use of best available antibodies in diagnoses of breast epithelial lesions. The following items are discussed: assessment of invasion, IHC in papillary lesions, identification of breast tumor subtypes, IHC in proliferative breast lesions, assessment of lymphatic space invasion, diagnosis of metaplastic breast carcinoma, IHC in Paget disease, use of cytokeratins in sentinel lymph node assessment, and diagnosis of breast carcinoma at metastatic sites. Because the main focus of this review is on diagnosis, receptor studies on breast carcinoma are briefly discussed and only a few general comments are made.

Department of Pathology, Magee-Women Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA

Correspondence: Rohit Bharagva, MD, Department of Pathology, Magee-Women Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213 (e-mail:

© 2007 Lippincott Williams & Wilkins, Inc.