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Podoplanin: A Novel Diagnostic Immunohistochemical Marker

Ordóñez, Nelson G. MD

Advances in Anatomic Pathology: March 2006 - Volume 13 - Issue 2 - p 83-88
doi: 10.1097/01.pap.0000213007.48479.94
New Antibody/Techniques

Podoplanin is a transmembrane mucoprotein recognized by the recently commercially available D2-40 monoclonal antibody. Recent investigations have shown that podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Podoplanin has also been shown to be strongly expressed in seminomas, epithelioid mesotheliomas, and hemangioblastomas, and immunostaining for this marker can assist in the diagnosis of these tumors. This article reviews the current information on the applications of podoplanin immunostaining in surgical pathology.

University of Texas, Anderson Cancer Center, Houston, TX

Reprints: Dr Nelson G. Ordóñez, MD, Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 (e-mail:

Received for publication March 2, 2006; accepted March 2, 2006

Copyright © 2006 Wolters Kluwer Health, Inc. All rights reserved.