REVIEW ARTICLESGene Expression in Neoplasms of the Pancreas: Applications to Diagnostic PathologyIacobuzio-Donahue, Christine A.; Hruban, Ralph H.Author Information Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, U.S.A. Address correspondence and reprint requests to Christine A. Iacobuzio-Donahue, M.D., Ph.D., Division of Gastrointestinal/Liver Pathology, Department of Pathology, Ross Building, Room 632, The Johns Hopkins Hospital, 720 Rutland Avenue, Baltimore, MD 21205–2196. E-mail: [email protected] Advances in Anatomic Pathology: May 2003 - Volume 10 - Issue 3 - p 125-134 Buy Abstract It seems that, lately, every pathology journal has three or four articles documenting the discovery of another genetic alteration or describing global gene expression in a series of cancers. Although these discoveries provide insight into the biology of neoplasia, it is less clear how they can be quickly and efficiently translated to patient care. This review will use neoplasms of the pancreas as a model and show how recent discoveries of genetic alterations and gene expression patterns can have a significant impact on the diagnosis and even treatment of tumors. Emphasis will be placed on applications that are practical and useful to the daily practice of pathology. © 2003 Lippincott Williams & Wilkins, Inc.