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Different Types of Epithelial Cadherin Alterations Play Different Roles in Human Carcinogenesis: On: Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. Huntsman DG, Carneiro F, Lewis FR, et al. New Eng J Med 2001; 344:1904–1909

Sobrinho-Simões, Manuel*†; Oliveira, Carla*

Advances in Anatomic Pathology: November 2002 - Volume 9 - Issue 6 - p 329-337
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Epithelial cadherin (E-cadherin) gene and protein alterations are implicated in the existence of two clearly distinct types of tumors in the stomach (isolated cell and glandular carcinomas), breast (lobular and ductal carcinomas), and thyroid (papillary and follicular carcinomas), as well as in the occurrence of poorly differentiated foci in colorectal and prostate adenocarcinomas. A thorough correlation between clinicopathologic features and molecular data, and the study of early lesions from familial cases provide clues for the understanding of the role played by E-cadherin in these settings.

At the *Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP); and the †Medical Faculty of the University of Porto, Portugal.

Address correspondence to Prof. Manuel Sobrinho-Simões, IPATIMUP, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal.

E-mail: ssimoes@ipatimup.pt.

© 2002 Lippincott Williams & Wilkins, Inc.