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Cytologic Diagnosis of Adenocarcinoma in Biliary and Pancreatic Duct Brushings

Henke, Andrew C.; Jensen, Chris S.; Cohen, Michael B.

Advances in Anatomic Pathology: September 2002 - Volume 9 - Issue 5 - p 301-308
Review Articles

Biliary and pancreatic duct brush specimens are relatively uncommon specimens seen by pathologists. Not only can the findings of malignancy be subtle, the implications of a malignant diagnosis can be significant. This review focuses on cholangiocarcinoma and pancreatic ductal adenocarcinoma sampled by endoscopic brush cytology, with an emphasis on diagnostic criteria for adenocarcinoma. In addition, assessment of specimen adequacy, utilization of liquid-based preparations, molecular diagnosis, and timing of liver transplantation in patients with primary sclerosing cholangitis are also briefly discussed.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, U.S.A.

Address correspondence and reprint requests to Dr. Michael B. Cohen, Department of Pathology, University of Iowa, 200 Hawkins Drive, 1117 ML Iowa City, IA 52242-1009.

© 2002 Lippincott Williams & Wilkins, Inc.