Review Article: PDF OnlyTelomerase Activity in Cancer A Magic Bullet or a Mirage?Soria, Jean-Charles*,†; Vielh, Philippe‡; El-Naggar, Adel K.§Author Information *Departmentof Medicine, Institut Gustave-Roussy, Villejitif, France; †Laboratoire de Radiobiologie et Oncologie, CEA, Fontenay aux Roses. France; ‡Department of Pathology (LRC-CEA#14), Institut Curie, Paris, France; and §Department of Pathology, M, D, Anderson Cancer Center, Houston, Texas, USA Advances in Anatomic Pathology: March 1998 - Volume 5 - Issue 2 - p 86-94 Buy Abstract Telomerase is an important enzyme required for maintenance of chromosome ends (telomeres) during cell division. Since elevated activity of telomerase has been selectively demonstrated in a large number of human cancers, it has generated considerable excitement as a potential cancer marker, a prognostic factor, and a target of possible anticancer strategy. This article details diagnostic, prognostic, and therapeutic prospects linked to the measurement of telomerase activity and the growing complexity of its regulation and function. © Williams & Wilkins 1998. All Rights Reserved.