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Acute Methamphetamine-Induced Hepatic and Pancreatic Ischemia

Merchant, Krupa MS*; Schammel, Christine PhD; Fulcher, James MD

The American Journal of Forensic Medicine and Pathology: April 24, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/PAF.0000000000000486
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Methamphetamine is a central nervous system stimulant that induces arousal, a positive mood, cardiac stimulation, and an acute improvement in cognitive domains. Its illicit exploitation is rapidly growing in North America. Typically, extended use of the drug induces organ damage via vasoconstriction and subsequent ischemia. This case specifically discusses hepatic and pancreatic pathology resulting from methamphetamine overdose alongside an unusual discovery of globally necrotic von Meyenburg complexes.

From the *University of South Carolina School of Medicine–Greenville; and

Pathology Associates, Greenville, SC.

Manuscript received January 14, 2019; accepted March 11, 2019.

The authors report no conflict of interest.

Reprints: James Fulcher, MD, 1190 W Faris Rd, Greenville, SC 29605. E-mail: JFulcher@ghs.org.

© 2019 by Lippincott Williams & Wilkins.