Case ReportsComplete Clinicopathological Case Report of a Young Patient Dying of COVID-19–Related StrokeTaylor, Laura D. MBChB, DipForMed(SA)Path, MMed Path (Foren), FCForPath (SA)∗; Ameen, Ozayr Saleh MBBCh, FCNeurol†; Zaharie, Stefan-Dan MBChB, EFN‡Author Information From the ∗Division of Forensic Medicine and Toxicology, University of Cape Town Faculty of Health Sciences †Melomed Gatesville Medical Centre ‡Division of Anatomical Pathology, Tygerberg Hospital, Cape Town, South Africa. Manuscript received October 5, 2020; accepted November 17, 2020. The authors declare no conflict of interest. Reprints: Laura D. Taylor, MBChB, DipForMed(SA)Path, MMed Path (Foren), FCForPath (SA), Division of Forensic Medicine and Toxicology, University of Cape Town Faculty of Health Sciences, Anzio Road, Observatory, 7705, Cape Town, South Africa. E-mail: [email protected]. Approval for the publication of this case report was received from the University of Cape Town Human Research Ethics Committee (study no. HREC 541/2020). Informed consent was also signed by the deceased's next of kin. The American Journal of Forensic Medicine and Pathology: June 2021 - Volume 42 - Issue 2 - p 160-163 doi: 10.1097/PAF.0000000000000668 Buy Metrics Abstract The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic has revealed diverse neurological manifestations of coronavirus disease 2019 (COVID-19). This case report begins with a background review of the neurological effects of COVID-19, focusing on stroke, neuroinflammation, and coagulopathy. It then describes the clinical course and autopsy findings of a young patient presenting with COVID-19–associated stroke. The formal neuropathological examination is presented, along with the systemic and brain histological features. Interesting aspects include multiterritory hemorrhagic infarctions, microinfarcts throughout the cortex and white matter, and prominent mixed inflammatory cell cuffing of intracerebral blood vessels distant from the infarcts. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.