Case ReportsNiemann-Pick Disease Type B in Traumatic Splenic RuptureZhao, Shuquan MD, PhD; Shi, Qing BD; Deng, Weinian BD; Zhou, Yiwu MD, PhDAuthor Information From the Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Manuscript received January 22, 2020; accepted April 24, 2020. Reprints: Yiwu Zhou, MD, PhD, Huazhong University of Science and Technology, Tongji Medical College, No. 13 Hangkong Rd, Wuhan 430030, People's Republic of China. E-mail: [email protected]. Written informed consent for publishing this scientific report was obtained from the patient in this case. This study was funded by the National Key Research and Development Program of China (2018YFC0807203). The authors declare no conflict of interest. The American Journal of Forensic Medicine and Pathology: September 2020 - Volume 41 - Issue 3 - p 227-229 doi: 10.1097/PAF.0000000000000577 Buy Metrics Abstract The rupture of spleen is common in clinical and forensic practice. Trauma is the most common cause of splenic rupture. Although rare, traumatic splenic rupture may occur in these individuals with asymptomatic underlying disease, and clinical and forensic pathologists may neglect the disease and diagnose only the traumatic splenic rupture. Here, we present a case of postinjury splenic rupture resulting in splenectomy, where the patient was diagnosed with Niemann-Pick disease type B through histopathological examination and genetic testing. In forensic practice, in cases of isolation splenic rupture, full microscopy should be done to differentiate traumatic rupture from a spontaneous bleed due to an underlying disease process. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.