A fatality following the ingestion of ibuprofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug widely prescribed as an analgesic, anti-inflammatory, and antipyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. We report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the emergency department by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt.
Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidone, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the emergency department, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography/mass spectrometry technique. The estimated ibuprofen concentration in the plasma was 600 μg/mL; gastric content was 200 μg/mL for this compound. Our report describes results of the forensic investigation and discuss the review of the literature.
From the *Institute of Legal Medicine, School of Medicine, Catholic University of the Sacred Heart, Rome; and †Forensic Science Department, Cagliari University, Monserrato (CA), Italy.
Manuscript received November 16, 2009; accepted March 27, 2010.
This study has been supported by Fondi di Ateneo, Linea D1, Università Cattolica del Sacro Cuore.
The authors report no conflicts of interest.
Reprints: Fabio De-Giorgio, MD, Institute of Legal Medicine, Catholic University, School of Medicine, L.go F. Vito 1, 00163 Rome. E-mail: firstname.lastname@example.org.