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Lymphangioma-like Variant of Kaposi's Sarcoma: Clinicopathologic Study of Seven Cases with Review of the Literature

Cossu, Sergio M.D.; Satta, Rosanna M.D.; Cottoni, Francesca M.D.; Massarelli, Giovannino M.D.

The American Journal of Dermatopathology: February 1997 - Volume 19 - Issue 1 - p 16-22
Articles

The clinical and pathological features of seven cases of lymphangioma-like Kaposi's sarcoma (KS) are reported. As with the other subtypes of KS, the lymphangioma-like variant occurs more often in men aged 59-80 years. Clinically, the lesion appears intermingled with the classical forms of KS, but a "bulla-like" appearance recognized in seven of 13 cases has been considered as a clinical hallmark of this variant. Although occasional cases have shown aggressive behavior, the most frequent clinical course is slowly progressive with localized or diffuse involvement of lower limbs. The histological pattern, characterized by permeation of dermal collagen by labyrinthine vascular channels lined by a flattened endothelium, must be differentiated from spindle cell hemangioendothelioma, low-grade angiosarcoma, targetoid hemosiderotic hemangioma, and benign lymphangioendothelioma.

From the Institute of Histopathology and Anatomical Pathology (S.C., G.M.) and the Institute of Dermatology (R.S., F.C.), University of Sassari, Sassari, Italy.

Address correspondence and reprint requests to Dr. Sergio Cossu, Institute of Histopathology and Anatomical Pathology, University of Sassari, Via Matteotti 58, 07100 Sassari, Italy.

© Lippincott-Raven Publishers