Brief ReportA Second Case of Localized Cutaneous Amyloid Elastosis: Expanding the Discussion of Associations With a Unique Histopathologic EntityRoberts, Sammie J. MD; Dittmer, Martin R. MD; Vidal, Claudia I. MD, PhD; Sellinger, Erin E. MD; Hurley, M. Yadira MDAuthor Information Saint Louis University School of Medicine, Department of Dermatology, St. Louis, MO. Dr. Roberts is now with the University of Colorado Anschutz Medical Campus, Department of Pathology, Aurora, CO. Dr. Vidal is now with the Dermatology Center of Southern Indiana, Bloomington, IN. Dr. Sellinger is now with the United Skin Specialists, Plymouth, MN. Correspondence: Sammie J. Roberts, MD, 12605 E. 16th Avenue Mail Stop F768, Anschutz Inpatient Pavilion 1, Aurora, CO 80045 (e-mail: [email protected]). The authors declare no conflicts of interest. The American Journal of Dermatopathology: January 2022 - Volume 44 - Issue 1 - p 43-48 doi: 10.1097/DAD.0000000000002001 Buy Metrics Abstract Amyloid elastosis is an exceedingly rare form of amyloidosis characterized by amyloid material deposited on dermal elastic fibers. Most reported cases have been associated with systemic amyloid light-chain amyloidosis. A single previously reported case of amyloid elastosis showed evidence that the amyloid material was derived from light-chain proteins and was associated with a monoclonal plasma cell infiltrate but failed to demonstrate systemic involvement. As a result, the case was felt to represent localized cutaneous amyloid elastosis. We present a case of localized cutaneous amyloid elastosis that is not associated with a definitive monotypic plasma cell population or with systemic amyloidosis. We also review the clinical and histopathologic features of reported cases of amyloid elastosis and discuss possible etiologic considerations. Because amyloid elastosis can be either localized to the skin or associated with systemic involvement, additional workup to exclude an underlying plasma cell dyscrasia or hematologic malignancy is warranted. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.