CME ArticleSebaceous Carcinomas: A Clinicopathological Comparison of Ocular and Extraocular VariantsPlaza, Jose A. MD*; Chung, Catherine MD†; Salim, Sadia MD‡; Gru, Alejandro MD§; Sangueza, Martin MD¶Author Information *Director of Dermatopathology, The Ohio State University Wexner Medical Center, Columbus, OH; †Dermatopathologist, The Ohio State University Wexner Medical Center, Columbus, OH; ‡Dermatopathologist, Inform Diagnostic Irving, Irving, TX; §Director of Dermatopathology, Divisions of Dermatopathology and Hematopathology, University of Virginia, Charlottesville, VA; and ¶Director of Pathology, Hospital Obrero, La Paz, Bolivia, South America. Correspondence: Jose A. Plaza, MD, Director of Dermatopathology, The Ohio State University Wexner Medical Center, 930 Martha Morehouse Tower, 2050 Kenny Road, Columbus, OH 43221 (e-mail: josea.plaza[email protected]). All authors, faculty, and staff in a position to control the content of this CME activity have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations relevant to this educational activity. Reviewed and approved by The Ohio State University Wexner Medical Center IRB; approval #2020E0308. The American Journal of Dermatopathology: November 2021 - Volume 43 - Issue 11 - p 763-772 doi: 10.1097/DAD.0000000000001812 Buy CME Test Metrics Abstract Sebaceous carcinomas (SC) are rare tumors and are currently classified into ocular and extraocular variants. Both variants of SC have very different clinical behavior and different histomorphologic appearance; however, published data are confounding as literature describes prognosis of both variants is similar or even that extraocular variants are more aggressive. In this study we evaluated the clinical and the histopathology of ocular and extraocular SC to confirm the difference between them. We performed a retrospective review of SC in which we studied the clinical and histomorphologic features of 106 cases, including 39 cases of ocular SC and 67 cases of extraocular SC. Only 2/67 cases of extraocular SC had multiple recurrences and none of them metastasized as opposed to our cases of ocular SC wherein 21/39 cases were locally aggressive with multiple recurrences and 5 cases metastasized. Histologically, both neoplasms showed major distinct morphologic features including poor differentiation in cases of ocular SC and well-differentiated tumors in the extraocular anatomic sites. To the best of our knowledge, this is the first case series of SC that compares the clinicopathologic features of ocular and extraocular variants. Awareness of such discrepancy is key to understand this disease and to possibly diagnose and manage these patients accordingly. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.