Extraordinary Case ReportSolitary CD8-Positive Primary Cutaneous Peripheral T-Cell Lymphoma: A Question of ClassificationRolim, Inês MD*; BakShi, Arti MBBS, MD, FRCpath†; West, Elizabeth MBBcH‡; Azurdia, Richard BMedSci, BMBS, FRCP‡; Kempf, Werner MD§; Robson, Alistair FRCPath, DipRCPath¶ Author Information *Anatomic Pathology Service, Champalimaud Clinical Centre (CCC), Lisbon, Portugal; †Department of Pathology, Royal Liverpool and Broadgreen University Hospitals NHS trust, Liverpool, United Kingdom; ‡Department of Dermatology, Royal Liverpool and Broadgreen University Hospitals NHS trust, Liverpool, United Kingdom; §Kempf und Pfaltz Histologische Diagnostik and Department of Dermatology, University Hospital Zurich, Zurich, Switzerland; and ¶Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisboa, Portugal. Correspondence: Alistair Robson, Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E., Rua Prof. Lima Basto, 1099-023 Lisbon, Portugal (e-mail: [email protected]). The authors declare no conflicts of interest. The American Journal of Dermatopathology: September 2021 - Volume 43 - Issue 9 - p e107-e110 doi: 10.1097/DAD.0000000000001908 Buy Metrics Abstract Acral CD8(+) lymphoma is a provisional entity in the latest edition of the WHO Lymphoma Classification and is associated with a highly specific dot-like pattern of immunohistochemical expression of CD68. We report a case of an ulcerated solitary cutaneous lesion arising on the forehead of an adult man, which had a CD8(+) cytotoxic phenotype and areas of dot-like CD68 positivity, but with a number of features that significantly detracted from the classically described acral CD8(+) lymphoma. The nosological status of the lesion is discussed with respect to a preferred diagnosis of peripheral T-cell lymphoma, not otherwise specified. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.