CME ArticleOsteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying PathogenesisHamie, Lamiaa MD*; Abbas, Ossama MD†; Kurban, Mazen MD‡; Bhawan, Jag MD§Author Information *Dermatology Resident, Dermatology Department, American University of Beirut, Beirut, Lebanon; †Professor, Dermatology Department, American University of Beirut, Beirut, Lebanon; ‡Associate Professor, Dermatology Department, American University of Beirut, Beirut, Lebanon; and §Professor, Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA. Correspondence: Jag Bhawan, MD, Dermatopathology Section, Dermatology Department, Boston University School of Medicine, 609 Albany Street, J-309, Boston, MA 02118 (e-mail: [email protected]). L. Hamie and O. Abbas authors contributed equally to the manuscript. All authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations relevant to this educational activity. The American Journal of Dermatopathology: March 2021 - Volume 43 - Issue 3 - p 163-173 doi: 10.1097/DAD.0000000000001769 Buy CME Test Metrics Abstract Osteoclast-like giant cells (OLGCs) resemble osteoclasts with their abundant cytoplasm and well-developed organelles. OLGCs are characteristic features of giant cell tumor of the tendon sheath and giant cell tumor of soft tissue but they have also been described in numerous other cutaneous conditions. The diagnostic and prognostic significance of the presence of OLGCs is unknown. Here, we summarize the clinical entities that can exhibit these cells to avoid a histological overlap, affecting diagnosis and management. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.