CME ArticleNeuroendocrine Differentiation of Skin Tumors: A Comprehensive ReviewHamie, Lamiaa MD*; Abbas, Ossama MD†; Bhawan, Jag MD‡Author Information *Dermatology Resident, Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon; †Professor, Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon; and ‡Professor, Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA. Correspondence: Jag Bhawan, MD, Guido Majno Professor of Dermatology and Pathology, Head, Dermatopathology Section, Vice Chairman, Department of Dermatology, Boston University School of Medicine, 609 Albany Street, J-308, Boston, MA 02118 (e-mail: [email protected]). All authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations relevant to this educational activity. The American Journal of Dermatopathology: December 2020 - Volume 42 - Issue 12 - p 899-910 doi: 10.1097/DAD.0000000000001664 Buy CME Test Metrics Abstract Neuroendocrine differentiation is characterized by endocrine and neuronal features with prominent dense secretory granules and neuropeptides. Neuroendocrine differentiation of skin tumors is of unknown clinical significance. Nonetheless, the acknowledgment of this line of differentiation is important to prevent diagnostic pitfalls and subsequent inappropriate management. This review aims at summarizing the skin neoplasms that can express neuroendocrine markers. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.