CME ArticleMolecular Diagnostics of Vascular Tumors of the SkinLlamas-Velasco, Mar MD*; Mentzel, Thomas MD†,‡Author Information *Dermatologist, Dermatology Department, Hospital Universitario de La Princesa, Madrid, Spain; †Pathologist, Dermatopathology Department, Dermatopathologie Bodensee, Friedrichshafen, Germany; and ‡Associated Professor, Department of Pathology, University of Freiburg, Freiburg, Germany. Correspondence: Mar Llamas-Velasco, MD, Hospital de La Princesa, C/Diego de León 62, CP 28006 Madrid, Spain (e-mail: [email protected]). All authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations relevant to this educational activity. The American Journal of Dermatopathology: November 2020 - Volume 42 - Issue 11 - p 799-810 doi: 10.1097/DAD.0000000000001663 Buy CME Test Metrics Abstract In this article, the authors have reviewed all the recent news regarding how the discovery of some novel and recurrent molecular and genetic changes has modified the classification of some entities and have addressed to the description of new variants of vascular tumors. And even more important, the authors also reviewed on how these findings, in addition to gain insight into the tumoral biology, portend significant clinical consequences not only regarding to their diagnosis but also to their management and prognosis because some of these mutations are potential targets for treatment. The authors have also highlighted immunohistochemical markers can help us as a surrogate marker of those molecular alterations. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.