Extraordinary Case ReportBasomelanocytic Neoplasms: A Report of Two Similar Tumors With Divergent TreatmentsRyan, Michael P. BS*; Bennett, Daniel D. MD†; Goodwin, Brandon P. MD‡; Kelly, Brent C. MD‡Author Information *School of Medicine, University of Texas Medical Branch, Galveston, TX; †Department of Dermatology, University of Wisconsin, Madison, WI; and ‡Department of Dermatology, University of Texas Medical Branch, Galveston, TX. Correspondence: Michael P. Ryan, BS, University of Texas Medical Branch, Galveston, TX 77555-0783 (e-mail: firstname.lastname@example.org). The authors declare no conflicts of interest. A Poster Presentation has been submitted for The American Society of Dermatopathology Annual Meeting; October 17–20, 2019; San Diego, CA. IRB approval was not required. Article is not under consideration for publication elsewhere. The American Journal of Dermatopathology: July 2020 - Volume 42 - Issue 7 - p 530-532 doi: 10.1097/DAD.0000000000001555 Buy Metrics Abstract Basomelanocytic neoplasms are tumors consisting of elements of both basal cell carcinoma and melanoma. These tumors are exceedingly rare and present a unique challenge as to how the melanoma component should be classified. Due to the paucity of cases, there are no clear-cut evidence-based guidelines as to how these tumors should be staged and which treatment options provide the optimal outcome. We present 2 separate patients with similar cases of colonizing basomelanocytic tumors that were treated in drastically different ways, highlighting the differing approaches to treatment. We discuss theses treatment modalities and the challenges inherent to diagnosing and treating basomelanocytic neoplasms. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.