Review ArticleAtypical Disseminated Variant of Galli–Galli Disease: A Review of the LiteratureYang, Anes MD, BMed, MPH*,†,‡; Cheung, Karen MBBS, FRCPA‡,§; Kossard, Steven MBBS, FACD, PhD, Hon, FRCPA¶; Murrell, Dedee F. MA, BMBCh, FAAD, MD, FACD, FRCP*,†,‡Author Information *Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia; †University of New South Wales, Sydney, New South Wales, Australia; ‡University of Sydney, Sydney, New South Wales, Australia; §The Skin Hospital, Sydney, New South Wales, Australia; and ¶Kossard Dermatopathologists, Sydney, New South Wales, Australia. Correspondence: Dedee F. Murrell, MA, BMBCh, FAAD, MD, FACD, FRCP, Professor, Department Dermatology, St George Hospital, Gray Street, Kogarah, Sydney, New South Wales 2217, Australia (e-mail: firstname.lastname@example.org). The authors declare no conflicts of interest. The American Journal of Dermatopathology: July 2020 - Volume 42 - Issue 7 - p 484-490 doi: 10.1097/DAD.0000000000001467 Buy Metrics Abstract Galli–Galli disease (GGD) is a rare genodermatoses within the group of reticulated pigmentary disorders of the skin. Traditionally, its clinical presentation is identical to that of Dowling–Degos disease (DDD), with the additional feature of acantholysis on histopathological examination. We have reviewed the published cases of GGD to provide further support for the hypothesis that in fact, 2 phenotypes of GGD exist: the characteristic flexural GGD associated with KRT5 mutations and a disseminated variant with no mutation identified to date. A review of the literature revealed 53 reported cases of GGD. Fifteen atypical phenotype cases are described, and no KRT5 mutation has yet been identified. There is growing evidence that acantholysis is an underreported feature of DDD and that GGD and DDD are variations of the same disease, or in fact the same entity. This theory is supported by the identification of the c.418dupA missense mutation in both GGD and DDD. This review highlights that there is growing evidence that there are likely 2 clinical phenotypes of GGD with an associated genotypic correlation. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.