Brief ReportA Helpful Clue to Calciphylaxis: Subcutaneous Pseudoxanthoma Elasticum–like ChangesChen, Eric L. AB; Altman, Igor DO; Braniecki, Marylee MDAuthor Information Department of Pathology, University of Illinois College of Medicine, Chicago, IL. Correspondence: Eric L. Chen, AB, University of Illinois College of Medicine, 1740 W. Taylor Street, MC 847, Chicago, IL 60612 (e-mail: firstname.lastname@example.org). The authors declare no conflicts of interest. The American Journal of Dermatopathology: July 2020 - Volume 42 - Issue 7 - p 521-523 doi: 10.1097/DAD.0000000000001577 Buy Metrics Abstract Calciphylaxis, otherwise known as calcific uremic arteriolopathy, is an aggressive disease characterized by painful, ischemic skin lesions with histologic findings of microvascular calcification involving the fat. It is most commonly seen in patients with end-stage renal disease who are on dialysis. Early diagnosis is pivotal for optimal management. However, calciphylaxis can be challenging to diagnose, as many diseases can bear a clinical resemblance to calciphylaxis. Skin biopsies are often necessitated for diagnosis, but unfortunately, one is commonly challenged with a suboptimal amount of subcutaneous fat that does not always show the classic findings of microvascular calcification. However, when calciphylaxis is clinically suspected, the microscopic detection of subcutaneous pseudoxanthoma elasticum (PXE)-like changes, although not unequivocally diagnostic of calciphylaxis, can be a helpful clue in the diagnosis. We report a case of a 49-year-old woman who was diagnosed with uremic calciphylaxis on the basis of the clinical scenario, laboratory testing, and microscopic presence of subcutaneous PXE-like changes that was highlighted with the elastic and von Kossa stains. This case demonstrates the importance of recognizing subcutaneous PXE-like changes on suboptimal skin biopsies that lack microvascular calcification, especially in those patients who are clinically suspect for calciphylaxis as to prevent delay in diagnosis and treatment. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.