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Sarcomatoid Variant of Primary Cutaneous Anaplastic Large Cell Lymphoma

Natsuaki, Yohei MD, PhD*; Muto, Ikko MD*; Kawamura, Miyuki MD*; Saruta, Hiroshi MD, PhD*; Teye, Kwesi PhD; Ohshima, Koichi MD, PhD; Nakama, Takekuni MD, PhD*; Ohata, Chika MD, PhD*

The American Journal of Dermatopathology: December 2019 - Volume 41 - Issue 12 - p e164–e167
doi: 10.1097/DAD.0000000000001483
Extraordinary Case Report
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Abstract: Sarcomatoid variant of primary cutaneous anaplastic large cell lymphoma is rare and is a diagnostic challenge. Clinical manifestation often mimics that of an infectious disease. Predominance of spindle cells in the biopsy specimen prevents from suspecting lymphoma. Here, we report the fourth case of this entity with good prognosis. A 30-year-old woman presented with several nodules on the whole body. The biopsy revealed infiltration of spindle cells in the dermis with myxomatous background. The spindle cells were positive for CD4 and CD30 and negative for CD3, CD8, CD20, and anaplastic lymphoma kinase. Although most of the skin lesions spontaneously resolved, a new red nodule progressively expanded on the left axilla. Finally, the patient received chemotherapy, which resulted in complete remission. The patient is free of disease for 18 months.

*Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan;

Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan; and

Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.

Correspondence: Chika Ohata, MD, PhD, Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan (e-mail: bboohay02@ybb.ne.jp).

The authors declare no conflicts of interest.

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