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Intravascular Colonization of Kaposi Sarcoma

Expanding the Spectrum of Specific Infiltrates of B-Cell Chronic Lymphocytic Leukemia

Saggini, Andrea MD*; Del Poeta, Giovanni MD; Santinelli, Enrico MD; Bianchi, Luca MD; Caposiena Caro, Raffaele D. MD; Orlandi, Augusto MD*

The American Journal of Dermatopathology: December 2019 - Volume 41 - Issue 12 - p 940–944
doi: 10.1097/DAD.0000000000001481
Extraordinary Case Report
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Abstract: B-cell chronic lymphocytic leukemia (CLL), a low-grade malignancy consisting of CD5(+), CD23(+), and CD43(+) small B lymphocytes, is the most frequent leukemia in the western world. Patients with CLL may exhibit skin changes characterized by histopathologic evidence of infiltration by atypical B lymphocytes, also known as “specific cutaneous infiltrates of CLL”; in addition, CLL is known to be associated with an increased risk of second cancers, including Kaposi sarcoma (KS). The combination of KS and CLL within the same cutaneous biopsy specimen has only rarely been described. We report a peculiar case of KS occurring in a patient with CLL, in which histopathological evaluation of KS lesions revealed prominent accumulation of CLL lymphocytes within neoplastic vascular spaces. We believe that our findings represent a novel example of intravascular colonization of vascular neoplasms by neoplastic lymphoid cells, further expanding the evergrowing spectrum of specific cutaneous infiltrates of CLL.

*Anatomic Pathology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy;

Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; and

Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Correspondence: Andrea Saggini, MD, Anatomic Pathology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, 00173 Rome, Italy (e-mail: andreasaggini@gmail.com).

The authors declare no conflicts of interest.

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