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Epstein–Barr Virus–Induced Cutaneous Diffuse Large B-Cell Lymphoma in a Patient With Angioimmunoblastic T-Cell Lymphoma

Poon, Flora MBBS, MHSc*; Ieremia, Eleni FRCPath, DipRCPath(Derm); Collins, Graham MRCP, FRCPath, DPhil; Matin, Rubeta N. PhD, FRCP(Derm)*

The American Journal of Dermatopathology: December 2019 - Volume 41 - Issue 12 - p 927–930
doi: 10.1097/DAD.0000000000001371
Extraordinary Case Report
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Abstract: Cutaneous manifestations of Epstein–Barr virus (EBV)-driven B-cell lymphoid proliferations occur rarely as a result of severe immunodeficiency. To date, only a few cases of extranodal EBV-associated B-cell lymphomas arising in patients with angioimmunoblastic T-cell lymphoma (AITL) have been reported, and less common is a cutaneous presentation. AITL is a rare aggressive tumor that carries a poor prognosis and prompt diagnosis, and recognition of EBV-associated diffuse B-cell lymphoma is essential in these patients to instigate the correct treatment.

*Department of Dermatology, NHS Foundation Trust, Oxford University Hospitals, Oxford, United Kingdom;

Department of Cellular Pathology, NHS Foundation Trust, Oxford University Hospitals, Oxford, United Kingdom; and

Department of Haematology, NHS Foundation Trust, Oxford University Hospitals, Oxford, United Kingdom.

Correspondence: Flora Poon, Department of Dermatology, Monash Health, 246 Clayton Road, Clayton, Victoria 3168, Australia (e-mail: flora.poon@hotmail.com).

The authors declare no conflicts of interest.

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