Immunoglobulin gamma (Ig) type 4–related disease (IgG4-RD) is a chronic immunologic systemic disorder that has gained worldwide recognition in the past decade. This entity can affect almost every organ system, and its characteristic lesions have been found in a variety of organs such as lacrimal and salivary glands, pancreas, liver, bile ducts, lungs, kidneys, retroperitoneum, breast, aorta, thyroid, and prostate. This case reports a very rare case of IgG4-RD presenting with a cutaneous lesion in a young female patient mimicking a lymphoproliferative disorder. IgG4-RD affecting the skin is a rare entity and has mostly been reported in Japanese men of middle to older age. IgG4-RD with cutaneous involvement should be in the differential of non-neoplastic, lymphomas, autoimmune, and infectious disorders of the skin.
*University of Virginia School of Medicine, Charlottesville, VA;
†Department of Dermatology, University of Virginia School of Medicine, Charlottesville, VA; and
‡Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA.
Correspondence: Aria Shakeri, HBSc, University of Virginia School of Medicine, 1215 Lee Street, 22908, Charlottesville, VA (e-mail: email@example.com).
A. A. Gru has a consultant and advisory board relationship with Seattle Genetics and BMS. The remaining authors declare no conflicts of interest.