Extraordinary Case ReportEndometriosis of the Eyelid, an Extraordinary Extra-abdominal Location Highlighting the Spectrum of DiseaseSharghi, Kevin G. MD*; Ramey, Nicholas A. MD†; Rush, Patrick S. DO*,‡; Grider, Douglas J. MD‡ Author Information *Division of Dermatology, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA; †Ophthalmology, Vistar Eye Center, Roanoke, VA; and ‡Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA. Correspondence: Patrick S. Rush, DO (e-mail: [email protected]). The authors declare no conflicts of interest. The American Journal of Dermatopathology: August 2019 - Volume 41 - Issue 8 - p 593-595 doi: 10.1097/DAD.0000000000001386 Buy Metrics Abstract Cutaneous endometriosis is an uncommon dermatologic disorder predominantly seen in young women. Most commonly, it presents within a region of a previous surgical scar, often in relation to a gynecologic procedure on the abdomen or in close proximity to the umbilicus. The typical clinical presentation is that of papules or nodules with monthly cyclical pain and size variation. Histologically, the lesions are composed of endometrial stroma and glands. The pathophysiology is not well understood but is believed to be due to metastasis or seeding of endometrial cells. When this uncommon disorder occurs outside of the most typical clinical setting, it may cause some diagnostic difficulty. In this report, we present the first known case of cutaneous endometriosis on the eyelid. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.